Why No Folate and B12


While folate and B12 are essential, not everyone benefits from having them included in a B-complex supplement. Here’s why you might choose a B-complex without folate and B12:

1. Individualised Supplementation is More Effective

Folate and B12 work best when taken in the right form and dose for your specific needs. Many B-complex supplements contain forms that may not be suitable for everyone.

  • Folate sensitivity – Some people need methylfolate instead of synthetic folic acid.
  • B12 absorption issues – The type of B12 matters, especially for those with absorption difficulties.

2. MTHFR Gene Mutations and Folate Processing

People with MTHFR mutations struggle to convert folic acid into its active form (methylfolate). Regular folic acid can be ineffective or even harmful, as it may build up in the body.

For these individuals, it's better to supplement with methylfolate separately rather than relying on a standard B-complex.

3. B12 Can Mask a Folate Deficiency (and Vice Versa)

Folate and B12 work together, but high doses of one can hide a deficiency of the other.

  • Excess folate can mask a B12 deficiency, which may lead to neurological damage if left untreated.
  • If you are unsure about your levels, it's best to test and supplement separately rather than relying on a B-complex.

4. High Doses of B12 Aren’t Always Necessary

Many B-complex supplements contain large amounts of B12, which may not be needed by everyone.

  • People with enough dietary B12 (from meat, dairy, or fortified foods) may not need extra supplementation.
  • Those with B12 absorption issues (like pernicious anemia) require injections or sublingual B12 instead of oral supplements.

5. A Targeted B-Complex Formula May Be Better

Fettyl B Complex without 6, 9 & 12 is ideal for those who:

  • Prefer to take these vitamins separately to control form and dosage.
  • Have MTHFR mutations and require specific folate forms.
  • Already get enough B12 from diet or separate supplementation.
  • Want to avoid potential interactions or imbalances between B vitamins.

If you're considering a B-complex supplement, checking the forms and amounts of folate and B12 is essential. Many people benefit more from taking these vitamins separately to ensure they're getting the right type and dosage for their needs.